Polybrominated diphenyl ethers (PBDEs) have been extensively used as additive flame retardants since the 1970s. Their concentrations have been reported to increase with time both in humans and in wildlife from all environmental compartments. Retrospective time-trend studies conducted using environmental samples originating from the Swedish environment showed a peak in environmental levels in the mid-1980’s, after which environmental concentrations decreased or remained unchanged. In Swedish human breast milk, the concentrations of low-medium brominated diphenyl ethers redoubled every 5 years until the late 1990s; thereafter a decrease has been indicated, at least for BDE-475. However, there is yet no information on human time trends for hepta-, octa-, nona- and deca-BDEs, neither in Sweden or elsewhere. Further, no longitudinal studies on individual basis have yet been reported. In 1991 men with a high dietary intake of fish from the Baltic Sea, 12–20 meals/month, had considerably higher BDE-47 levels than men with negligible consumption of fish. These men were resampled in 2001. Time trends for PCB and DDE have been reported elsewhere. Here, we report data on time trends for PBDEs in these men.