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Screening of Poly- and Perfluoroalkyl Substances (PFASs) and Extractable Organic Fluorine (EOF) in the Blood of Highly Exposed People
Executive, Universitet, Örebro universitet.
Executive, Universitet, Örebro universitet.
Executive, Universitet, Örebro universitet.
Executive, Universitet, Örebro universitet.
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2020 (English)Report (Other academic)Alternative title
Analyser av PFAS-prekursorer o extraherbart organiskt fluor (EOF) från individer boende i Ronneby med hög PFAS-exponering (Swedish)
Abstract [en]

This report summarises the findings of an investigation into the occurrence of poly- and perfluoroalkyl substances (PFASs) in the whole blood of people living in the municipality of Ronneby. A total of 20 whole blood samples from individuals who have known to been expose to PFASs via consumption of PFAS contaminated drinking water were analysed in this study. Using both liquid and supercritical chromatography coupled with tandem mass spectrometers a total of 63 PFASs were analysed. These results were then compared with extractable organofluorine (EOF) levels measured with combustion ion chromatography. The data from both target PFAS analysis and EOF was used to perform fluorine mass balance analysis.

In general, the PFAS profile was dominated by long-chain perfluoroalkyl sulfonates (PFSAs with more than 6 fluorinated carbons), on average accounting for 97% of the total PFAS budget. The second most prominent PFAS class were long-chain perfluoroalkyl carboxylates (PFCAs with more than 7 fluorinated carbons), accounting for an additional 2.6% of the PFAS exposure. The average sum PFAS concentrations was 346 ng/g (from 74.1 ng/g to 715 ng/g). The average EOF concentration was 186 ng F/g and 79% of the EOF was explained by the target analytes.

Abstract [sv]

Denna rapport redovisar resultaten från en studie angående förekomsten av poly- och perfluoroalkylsubstanser (PFAS) i helblodsprover hos människor som bor i Ronneby kommun. Totalt har 20 helblodsprover analyserats i studien. Totalt analyserades 63 PFAS-ämnen genom att använda både vätske- och superkritisk vätskekromatografi kopplad till masspektrometrisk detektion. Dessa resultat jämfördes sedan med de detekterade halterna av extraherbart organisk fluor (EOF) i en massbalans analys av fluor.

PFAS profilen i blodproverna dominerades generellt av långkedjiga perfluoralkyl-sulfonsyror (PFSA med fler än sex fluorerade kol), vilket i genomsnitt stod för 97% av den totala PFAS-halten. Den näst mest framträdande PFAS klassen var långkedjiga perfluoroalkyl-karboxylsyror (PFCA med fler än sju fluorerade kol) som utgjorde ytterligare 2.6% av PFAS exponeringen. Den genomsnittliga summan av PFAS koncentrationerna var 346 ng/g (74.1 – 715 ng/g). Den genomsnittliga summan av EOF halten var 186 ng F/g, vilket innebar att 79% av EOF var identifierade ämnen.

Place, publisher, year, edition, pages
Örebro: Örebro universitet , 2020. , p. 37
Keywords [sv]
Ronneby, blod, PFAS, EOF, novel PFAS, ultrakort PFAS
National Category
Environmental Sciences
Research subject
Finance, National; Miljöövervakning, Health; Environmental Objectives, A Non-Toxic Environment
Identifiers
URN: urn:nbn:se:naturvardsverket:diva-8533OAI: oai:DiVA.org:naturvardsverket-8533DiVA, id: diva2:1460116
Available from: 2020-08-21 Created: 2020-08-21 Last updated: 2022-02-25

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